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pentobarbital will minimize the level or influence of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Diminished AUC of tramadol as well as the Lively metabolite (O-desmethyltramadol) when coadministered with robust CYP3A4 and CYP2B6 inducersAs an alternative to researching the tectonic shifts from the